Understanding The Accumulation Of Interstrand Crosslink Damaging Agents in Fanconi Anemia Cells

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Vikas T.Dongardive, Assistant professor SSBT’s COET, Bambhori, Jalgaon
Jayant P. Parpalliwar, Assistant professor, SSBT’s COET, Bambhori, Jalgaon

Fanconi Anemia (FA) is the result of dysfunctional protein in FA pathway which is required for the repairing the inter crosslink DNA (ICL) damage. It is well known that the presence of oxidative stress is more in FA cells. Oxidative stress is involved in DNA damage but it not clear how it is involved in interstrand crosslink. Interstrand crosslink agents are produced endogenously (like acetaldehyde/ formaldehyde) and exogenously (Alkylating agents). In alcohol metabolism pathway acetaldehyde/ formaldehyde are formed as intermediate product. In this study we tried to find the role of oxidative stress on interstrand crosslink. Interestingly the transcription of ADH5 has been found to be down regulated upon oxidative stress in HeLa cells. This study suggests that the oxidative stress may enhance accumulation of acetaldehyde/ formaldehyde in Fanconi cells.

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