Today, information has become very important resource and so is its security. Many traditional mathematical algorithms have been developed for encrypting the information or data for security purposes but they have limitations. Recently, biological techniques become more and more popular, as they are applied to many kinds of applications, authentication protocols, biochemistry, and cryptography[8]. One of the most interesting biology techniques is deoxyribonucleic acid and using it in such domains. Hiding secret data in deoxyribonucleic acid becomes an important and interesting research topic. DNA can be used not only to store and transmit the information, but also to perform computation. DNA[4] is used as an information carrier and modern biological technology is used as implementation tool, implementing data hiding based on DNA sequences to increase the complexity is the main target of this paper by using seed generation. The proposed method generated key with bit changing. The cipher text is generated with distributed permutation based poly substitution technique [8] and Transposition technique.